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Three of the most widely used serotonin supplements are the amino acids tryptophan, 5-HTP, and SAM-e.

Note that it is not considered safe to mix any of these amino acid supplements with antidepressant medications (4).

Serotonin is a neurotransmitter that plays a large role in mood, learning, appetite control, and sleep.It’s particularly helpful for Parkinson’s and schizophrenia patients who also have depression (14).SAM-e should not be mixed with drugs that affect serotonin release such as levodopa, Demerol, or Ultram, or the over-the-counter cough remedy Robitussin DM (15).Within a few months, this inevitably causes a cascade of negative side effects (10). Datis Kharrazian, author of , lists these co-factors as needed for the synthesis of either tryptophan or 5-HTP to serotonin — vitamins B3, B6, and B12, folic acid, and magnesium.Look either for serotonin boosting supplements that contain these along with the main active ingredients or add them separately with a high-quality multivitamin mineral supplement.

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